Anhui Medipharm Co., Ltd.  

Product Name: Sild Nafi Tablet 100mg GMP Medicine Model NO.: AMC12079-01 Type: Organic Chemicals Shape: Tablet State: Solid Suitable for: Doctor Usage Mode: For oral administration Application: Internal Medicine Registration: Available Trademark: OEM Transport Package: 4 Tablets Per Box Specification: 100mg Origin: China HS Code: 3004909099 Product Description CompositionEach film coated tablet contains.sidnafile Citral IP.eq.to Sildnafile 100mgExcipients q.s.Approved Colour used.Pharmacological Classification:Sildnaphile:Part of the physiologicalprocess of erection involves the Parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavemosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP) leadingto smooth muscle relaxation (vasodilation) in the corpus cavermosum resulting in increased inflow of blood and an erection Silden afile is apotent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which Is responsible for degradation of CGMP in thecorpus cavemosum. The molecular stiucture ofsild nafieerl is similar to that of CGMP and actsas a competitive binding agent of PDE5 in the corpuscavemosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack ofactivation of the NO/cGMP system, silden afile shouldnot cause an erection.Pharmacokinetics:onset of action: 60 minutes Duration 2-4 hours.Absorption: rapid, slower with a high fat meal.Distribution: Vdss: 105LProtein binding, plasma: 96%.metabolism:Hepatic via CYP3A4 (major) andCYP2C9(minor route) Bioavailability: 40%Half life elimination: 4 hoursTime to peak: 30-120 minutes, delayed by 60 minuteswith a high fat meal. Excretion: feces (80%) , urine (13%).Drug Interaction: azote.Antifungals: may increase the serumconcentrations of silden afirl; reduce starting dose to 25 mg.Alpha blockers (doxazosin):Concomitant use may leadto symptomatic, hypotension in somepatents, Patient should be stable onan alpha-biocker prior to initiation of PDE-5inhibitor. Silden afirl should be started at 25mg. This enzyme takes place in the body replacing an enzyme cGMP.PDE-5 also makes blood arteries hard. Due to it veins.(takes blood away from the penis) get expanded and arteries.takes blood toward the penis! get contracted.Adverse effect:potention: decreases In blood pressure mayoccur due to vasodilator effects.Disease Related ConcensAnatomical penis deformation: use with caution inpatientswith anatomical deformation of the penis. Bleedingdisorders:usewithcaution in patients with bleeding disorders; Safety and efficacy have not been established.Cardiovascular disease. use with extremecaution in patients with hypotension, uncontrolledhypertension, unstable angina or angina duringintercourse, severe cardiac failure, a life-threateningarrhythmia, or myocardial infarction within the last 3months safety efficacy have not been studiedin these patients.There is a degree of cardiac riskassociatedwith sexual activity; therefore, physicians may wish to consider the cardiovascularstatus of their patients prior to initiating anytreatmentfor erectile dysfunction. Conditions predisposing topriapism: use with caution in patients who have conditions Whichmay predispose them to priapism.Peptic ulcer disease:Use.with, caution in patientswith active peptic ulcer disease;safety and efficacy havenot been established.Stroke: use with caution in patients who have had astrokewithin the last 6 months: safety and efficacy have not been studied in these patients.Side effect: Amongst sild nafils rare butserious.adverse effects are: priapism, severe hypotension, myocardial infarction, ventricular arrhythmias, stroke and increaseIntraocular pressure.As with all prescription drugs, proper.dosage is at the discretion of a licensed medical doctor. Thedose of sild nafil is 25 mg to 100 mg taken once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50 mg and then lower or raise thedosage as appropriate.Storage:Store below 30ºC.PresentationBlister Pack of 4 tablets.Anhui Medipharm Co., Ltd.is one of the best medicinesuppliers in China. We have been focused on manufacturing and distributing western finished medicine products over 15 years. Our products have been exported to more than 60 countries, includingAsia, Africa, South America, Middle East and Europe.Professionalism, honesty and integrity are our cultures. We do our best to offer good quality products with competitive prices and fast delivery for our customers. We are looking forward to setting up long-term cooperation relationship with you.